Ethylene glycol acute poisoning treatment results in Kraków in the years 1990-1994

Przegl Lek. 1996;53(4):360-4.

Abstract

An analysis of ethylene glycol acute intoxication treatment results was performed in a group of 36 patients hospitalized within a five year period. Mean serum and urine glycol concentrations in the analyzed population ranged from 0-851 mg/dl (mean = 130 mg/dl) and from 12.4 to 930.0 mg/dl (mean 333 mg/dl), respectively. At the time of admission to the clinic 15 of 36 patients were deeply unconscious and mean acid-base balance values were as follows: pH 6.99, pCO2 16.7 mmHg, pO2 140.1 mmHg, HCO3 6.36 mmol/l, BE -29.6 mmol/l. Because of respiratory failure 21/36 patients (58.3%) required controlled ventilation and 24/36 (66.7%) underwent dialysis. Sixteen patients (44.4%) developed acute renal failure. Mean hospitalization period was 16 days (1-53). Eighteen patients (50%) died. The direct death mechanism in 15 patients (83.3%) was asystolia and in the remaining individuals other circulatory disturbances. The main reasons of high mortality rate were multiple organ damages secondary to severe metabolic acidosis.

MeSH terms

  • Acid-Base Imbalance / etiology
  • Acid-Base Imbalance / therapy*
  • Acidosis / etiology
  • Acidosis / mortality
  • Acidosis / prevention & control
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / therapy*
  • Adolescent
  • Adult
  • Cause of Death
  • Drug Overdose
  • Ethylene Glycol
  • Ethylene Glycols / blood
  • Ethylene Glycols / poisoning*
  • Ethylene Glycols / urine
  • Female
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Poland
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / therapy*
  • Survival Rate
  • Treatment Outcome

Substances

  • Ethylene Glycols
  • Ethylene Glycol