The observation that the insertion of a phenyl ring at position 3 of WB 4101 (1) afforded a potent and selective alpha 1-adrenoreceptor antagonist, phendioxan (2), prompted us to investigate the effect on alpha-adrenoreceptor blocking activity of replacing a hydrogen atom at the 2-position or on the 2-ylmethyl moiety of 1 and 2 by a methyl, ethyl or phenyl group. Thus compounds 3-11 were synthesized and their blocking activity and relative selectivity on alpha 1- and alpha 2-adrenoreceptors were evaluated in the isolated rat vas deferens in comparison to 1 and 2. The results of such investigation showed that this structural modification caused a decrease in affinity for alpha-adrenoreceptors.