Abstract
A certain number of benzodihydrocarbazoles and benzotetrahydrocycloheptindoles were synthesized and tested for their antimicrobial activity. Compounds substituted on the nitrogen of the tetracyclic systems with a dimethylaminopropyl chain showed an antibacterial activity directed almost exclusively towards Gram-positive bacteria, while their N-unsubstituted analogs were completely inactive.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Carbazoles / chemical synthesis*
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Carbazoles / pharmacology
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Microbial Sensitivity Tests
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Carbazoles
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Indoles