Abstract
The effect of Azidothymidine (AZT) in vivo on the replication of the Hepatitis B Virus (HBV) was studied in a population of 25 patients chronically coinfected by HBV and Human Immunodeficiency Virus Type 1 (HIV-1), and receiving AZT at the usual dosage. The drug effect was evaluated by sequential measurement of the HBV DNA level. No significant activity at short and medium term was found on HBV replication in either homosexuals or IV drug users chronically coinfected by HIV-1 and HBV.
MeSH terms
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Adult
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Antiviral Agents / therapeutic use*
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DNA, Viral / analysis
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy
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HIV Infections / virology
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HIV-1*
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Hepatitis B / complications*
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Hepatitis B / virology
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Hepatitis B virus / drug effects*
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Hepatitis B virus / genetics
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Hepatitis B virus / physiology
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Humans
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Male
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Middle Aged
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Sexual Behavior
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Substance Abuse, Intravenous
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Virus Replication / drug effects
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Zidovudine / therapeutic use*
Substances
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Antiviral Agents
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DNA, Viral
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Zidovudine