No association detected between a D3 receptor gene-expressed variant and schizophrenia

Am J Med Genet. 1996 Apr 9;67(2):232-4. doi: 10.1002/(SICI)1096-8628(19960409)67:2<232::AID-AJMG18>3.0.CO;2-K.

Abstract

A missense polymorphism (glycine to serine) in the first exon of the dopamine D3 (DRD3) gene was examined in the sib-pairs schizophrenia collection by the transmission test for linkage disequilibrium (TDT). No association due to linkage disequilibrium was detected using TDT. Additionally, no evidence for excess homozygosity was found.

MeSH terms

  • Genotype
  • Homozygote
  • Humans
  • Linkage Disequilibrium
  • Polymorphism, Genetic*
  • Receptors, Dopamine D2 / genetics*
  • Receptors, Dopamine D3
  • Schizophrenia / genetics*

Substances

  • DRD3 protein, human
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3