S-nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo

Synapse. 1996 May;23(1):58-60. doi: 10.1002/(SICI)1098-2396(199605)23:1<58::AID-SYN7>3.0.CO;2-G.

Abstract

Intranigral infusion of ferrous citrate (4.2 nmol) induced an acute lipid peroxidation in the substantia nigra and a chronic dopamine depletion in the striatum of rat nigrostriatal system. Coinfusion of 8.4 nmol nitric oxide donors such as S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) or nitric oxide (approximately 2 nmol) protected nigrostriatal neurons against iron-induced lipid peroxidation and associated oxidative injury. However, sodium nitroprusside (SNP, 8.4 nmol) augmented dopamine depletion caused by ferrous citrate because SNP is a ferricyanide complex. The present in vivo results indicate that nitric oxide and S-nitrosothiols are antioxidants which can protect brain dopamine neurons against oxidant stress/damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Corpus Striatum / drug effects*
  • Dopamine / metabolism*
  • Iron / pharmacology
  • Male
  • Mercaptoethanol*
  • Nitric Oxide / pharmacology*
  • Nitroprusside / pharmacology*
  • Nitroso Compounds / pharmacology*
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Sprague-Dawley
  • S-Nitrosothiols*
  • Substantia Nigra / drug effects*

Substances

  • Nitroso Compounds
  • S-Nitrosothiols
  • Nitroprusside
  • Nitric Oxide
  • Mercaptoethanol
  • S-nitrosomercaptoethanol
  • Iron
  • Dopamine