Abstract
A further cytochalasin was isolated from liquid culture filtrates of Phoma exigua var. heteromorpha together with cytochalasins U and V and other well-known cytochalasins. The metabolite, named cytochalasin W, was characterized by spectroscopic and chemical methods as a new 24-oxa[14]cytochalasan, bearing a formyl group on the macrocyclic ring. Cytochalasin W showed toxic activity in the brine shrimp assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Artemia / drug effects
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Chromatography, Thin Layer
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Culture Media
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Cytochalasins / chemistry
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Cytochalasins / isolation & purification*
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Cytochalasins / toxicity
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mitosporic Fungi / metabolism*
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Plant Leaves / metabolism
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Reference Standards
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
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Structure-Activity Relationship
Substances
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Culture Media
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Cytochalasins
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cytochalasin W