Abstract
The effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rats and guinea pigs was tested in vitro using isolated uterine horns. The volatile oil of Nigella sativa seeds inhibited the spontaneous movements of rat and guinea pig uterine smooth muscle and also the contractions induced by oxytocin stimulation. These effects were concentration-dependent and reversible by tissue washing. These data suggest that this volatile oil may have some anti-oxytocic potential.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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Female
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Guinea Pigs
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Magnoliopsida*
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Muscle Contraction / drug effects
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Muscle Relaxation / drug effects
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Muscle, Smooth / drug effects*
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Oils, Volatile / metabolism
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Oils, Volatile / pharmacology*
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Oxytocin / pharmacology
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Plant Oils / metabolism
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Plant Oils / pharmacology*
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Rats
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Seeds*
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Uterine Contraction / drug effects*
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Uterine Contraction / metabolism
Substances
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Oils, Volatile
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Plant Oils
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Oxytocin