Abstract
Ethanol intoxication produces deficits in the acquisition of new information and blocks the induction of hippocampal long-term potentiation (LTP), a candidate neurophysiological correlate for learning and memory. We report that, in adult rats, local application of the dopamine (DA) D1 receptor antagonist SCH-23390 into the lateral septum (LS) blocks ethanol-induced suppression of LTP and alterations of paired-pulse responses in the dentate gyrus. This suggests a primary role for an extra-hippocampal circuit and neurotransmitter system mediating ethanol's ability to suppress LTP.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Benzazepines / administration & dosage
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Benzazepines / pharmacology*
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Central Nervous System Depressants / antagonists & inhibitors
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Central Nervous System Depressants / pharmacology*
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Dentate Gyrus / drug effects
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Dentate Gyrus / physiology
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Dopamine / physiology
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Dopamine Antagonists / administration & dosage
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Dopamine Antagonists / pharmacology*
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Ethanol / pharmacology*
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Hippocampus / drug effects
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Hippocampus / physiology*
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Iontophoresis
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Long-Term Potentiation / drug effects*
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Male
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine D1 / antagonists & inhibitors
Substances
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Benzazepines
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Central Nervous System Depressants
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Dopamine Antagonists
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Receptors, Dopamine D1
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Ethanol
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Dopamine