Molecular cloning of a third chitinase gene (CHT1) from Candida albicans

Yeast. 1996 Apr;12(5):501-4. doi: 10.1002/(SICI)1097-0061(199604)12:5%3C501::AID-YEA931%3E3.0.CO;2-U.

Abstract

Here we report the complete nucleotide sequence of a third chitinase gene (CHT1) from the dimorphic human pathogen Candida albicans. The deduced amino acid (aa) sequence of Cht1 consists of 416 aa and displays 36% protein sequence similarity to chitinases Cht2 and Cht3, from C. albicans. Interestingly the domain structure of Cht1 is truncated when compared to the other chitinases of C. albicans and lacks a Ser/Thr-rich region.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Candida albicans / enzymology
  • Candida albicans / genetics*
  • Chitinases / chemistry
  • Chitinases / genetics*
  • Cloning, Molecular
  • Fungal Proteins*
  • Genes, Fungal / genetics*
  • Humans
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid

Substances

  • Fungal Proteins
  • Chitinases
  • Cht1 protein, Candida albicans

Associated data

  • GENBANK/U36490