L-Deprenyl augmentation of fluoxetine in a patient with Huntington's disease

Ann Clin Psychiatry. 1996 Mar;8(1):23-6. doi: 10.3109/10401239609149087.

Abstract

Fluoxetine and L-deprenyl were prescribed concurrently in a 19-year-old female with Huntington's disease. The patient showed significant affective, behavioral, and motoric improvements and there was no adverse effect resulting from this combination. Concomitant use of L-deprenyl in low doses and fluoxetine may be safe and beneficial in certain clinical situations, although further study is needed.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anticonvulsants / therapeutic use
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Attention / drug effects
  • Carbamazepine / therapeutic use
  • Depression / complications
  • Depression / drug therapy*
  • Drug Interactions
  • Drug Therapy, Combination
  • Expressed Emotion / drug effects*
  • Female
  • Fluoxetine / therapeutic use*
  • Humans
  • Huntington Disease / complications
  • Huntington Disease / drug therapy*
  • Impulsive Behavior / complications
  • Impulsive Behavior / drug therapy
  • Monoamine Oxidase Inhibitors / pharmacology
  • Monoamine Oxidase Inhibitors / therapeutic use*
  • Movement / drug effects
  • Selegiline / therapeutic use*
  • Violence

Substances

  • Anticonvulsants
  • Antidepressive Agents, Second-Generation
  • Monoamine Oxidase Inhibitors
  • Fluoxetine
  • Selegiline
  • Carbamazepine