Acute graft-versus-host disease with unusual cutaneous intracellular vacuolation in an infant with severe combined immunodeficiency

A Farrell; L Scerri; A Stevens; L G Millard

doi:10.1111/j.1525-1470.1995.tb00190.x

Acute graft-versus-host disease with unusual cutaneous intracellular vacuolation in an infant with severe combined immunodeficiency

Pediatr Dermatol. 1995 Dec;12(4):311-3. doi: 10.1111/j.1525-1470.1995.tb00190.x.

Authors

A Farrell¹, L Scerri, A Stevens, L G Millard

Affiliation

¹ Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.

PMID: 8747575
DOI: 10.1111/j.1525-1470.1995.tb00190.x

Abstract

We report an infant with severe combined immunodeficiency (SCID) who had cutaneous manifestations of acute graft-versus-host disease (GVHD) due to maternofetal lymphocyte engraftment. Histologic and ultrastructural examinations of the skin revealed intracellular vacuoles resembling lipid droplets in the epidermis and dermis, which is not a recognized feature of acute GVHD or SCID.

Publication types

Case Reports

MeSH terms

Acute Disease
Dermatitis, Exfoliative / complications
Dermatitis, Exfoliative / pathology
Female
Graft vs Host Disease / complications*
Humans
Infant
Keratinocytes / ultrastructure*
Lymphocytes / immunology
Male
Maternal-Fetal Exchange / immunology
Pregnancy
Severe Combined Immunodeficiency / complications*
Skin Diseases / complications*
Skin Diseases / pathology
Vacuoles / ultrastructure