Abstract
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca(2+)-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca(2+)-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.
MeSH terms
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Actins / genetics
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Animals
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Blotting, Northern
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Brain / physiology
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Calcium-Binding Proteins / drug effects
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Calcium-Binding Proteins / genetics*
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Excitatory Amino Acid Antagonists / pharmacology*
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Gene Expression / drug effects
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Male
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Nerve Tissue Proteins / drug effects
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Nerve Tissue Proteins / genetics*
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Neurocalcin
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Phencyclidine / pharmacology
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RNA, Messenger / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Calcium-Sensing*
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Schizophrenia / drug therapy
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Schizophrenia / physiopathology
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Time Factors
Substances
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Actins
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Calcium-Binding Proteins
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Excitatory Amino Acid Antagonists
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Nerve Tissue Proteins
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Neurocalcin
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RNA, Messenger
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Receptors, Calcium-Sensing
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Vsnl1 protein, rat
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Phencyclidine