Abstract
Cryptic t(12;21)(p12-13;q22) leading to TEL-AML1 fusion has recently been recognized as the most frequent genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) in Western countries. More recently, we found a similar frequency of this abnormality in Chinese children with ALL in Taiwan. In this study, we assessed further the frequency of TEL-AML1 fusion as well as that of BCR-ABL in Chinese adults with ALL, using reverse transcriptase-polymerase chain reaction assays. Among the 81 cases with newly diagnosed B lineage ALL studied, none had the TEL-AML1 fusion whereas 30 had the BCR-ABL fusion. The lack of cases with the TEL-AML1 fusion together with the high frequency of BCR-ABL fusion could largely account for the poorer outcome of adult ALL as compared with childhood ALL.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Base Sequence
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Chromosomes, Human, Pair 12*
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Chromosomes, Human, Pair 21*
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins / biosynthesis*
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DNA-Binding Proteins / genetics
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ETS Translocation Variant 6 Protein
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Female
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Humans
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Leukemia-Lymphoma, Adult T-Cell / metabolism*
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Male
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Middle Aged
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Molecular Sequence Data
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Oncogene Proteins, Fusion / biosynthesis*
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Oncogene Proteins, Fusion / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
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Proto-Oncogene Proteins c-ets
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Proto-Oncogene Proteins*
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Repressor Proteins*
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics
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Translocation, Genetic*
Substances
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins
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Neoplasm Proteins
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Oncogene Proteins, Fusion
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-ets
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RUNX1 protein, human
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Repressor Proteins
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Transcription Factors