The relationship between trinucleotide (GAA) repeat length and clinical features in Friedreich ataxia

Am J Hum Genet. 1996 Sep;59(3):554-60.

Abstract

Friedreich ataxia (FA) is associated with the expansion of a GAA trinucleotide repeat in the first intron of the X25 gene. We found both alleles expanded in 67 FA patients from 48 Italian families. Five patients from three families were compound heterozygotes with expansion on one allele and an isoleucine-->phenylalanine change at position 154 on the other one. We found neither expansions nor point mutations in three patients. The length of FA alleles ranged from 201 to 1,186 repeat units, with no overlap with the normal range, and showed a negatively skewed distribution with a peak between 800 and 1,000 repeats. The FA repeat showed meiotic instability with a median variation of 150 repeats. The lengths of both larger and smaller alleles in each patient inversely correlated with age at onset of the disorder. Smaller alleles showed the best correlation, accounting for approximately 50% of the variation of age at onset. Mean allele length was significantly higher in patients with diabetes and in those with cardiomyopathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Base Sequence
  • Cardiomyopathy, Hypertrophic / complications
  • Cardiomyopathy, Hypertrophic / genetics
  • Child
  • Child, Preschool
  • Diabetes Complications
  • Diabetes Mellitus / genetics
  • Disease Progression
  • Friedreich Ataxia / complications
  • Friedreich Ataxia / genetics*
  • Friedreich Ataxia / physiopathology*
  • Gene Frequency
  • Genotype
  • Humans
  • Italy
  • Molecular Sequence Data
  • Phenotype
  • Point Mutation / genetics*
  • Trinucleotide Repeats / genetics*
  • Wheelchairs

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