Abstract
From observations made on the rhythms in different systems: changes in plasmatic concentrations of 5-fluorouracil administered at a constant rate, proliferative activity of human tissues (bone marrow and oral mucosa), actometry, variations of glutathione levels in the liver and kidney from ice, we show the existence of a 12 hours rhythmic component and we discuss the putative importance of this component.
MeSH terms
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Adult
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Animals
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Antimetabolites / pharmacology
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Antimetabolites, Antineoplastic / blood*
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Antimetabolites, Antineoplastic / therapeutic use
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Bone Marrow Cells
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Buthionine Sulfoximine
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Cell Division / physiology
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Circadian Rhythm / physiology*
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Colorectal Neoplasms / blood*
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Colorectal Neoplasms / drug therapy
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Colorectal Neoplasms / pathology
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Depression, Chemical
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Female
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Fluorouracil / blood*
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Fluorouracil / therapeutic use
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Glutathione / biosynthesis
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Humans
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Kidney / drug effects
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Kidney / metabolism
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Liver / drug effects
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Liver / metabolism
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Male
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Methionine Sulfoximine / analogs & derivatives
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Methionine Sulfoximine / pharmacology
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Mice
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Motor Activity / physiology*
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Mouth Mucosa / cytology
Substances
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Antimetabolites
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Antimetabolites, Antineoplastic
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Methionine Sulfoximine
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Buthionine Sulfoximine
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Glutathione
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Fluorouracil