We report on a 55 year-old women with spontaneous remission of a primary cerebral lymphoma. Initial CT scan showed a left hemispheric lesion. With steroid therapy, this lesion disappeared. Nine months later, a new lesion appeared in the right frontal lobe. Follow-up CT scan 3 weeks later, without any treatment, showed complete resolution of this lesion. We conclude that primary cerebral lymphoma may have spontaneous remission.