Engineering hybrid pseudomonads capable of utilizing a wide range of aromatic hydrocarbons and of efficient degradation of trichloroethylene

J Bacteriol. 1996 Jul;178(14):4039-46. doi: 10.1128/jb.178.14.4039-4046.1996.

Abstract

We constructed hybrid Pseudomonas strains in which the bphA1 gene (coding for a large subunit of biphenyl dioxygenase) is replaced with the todC1 gene (coding for a large subunit of toluene dioxygenase of Pseudomonas putida Fl) within chromosomal biphenyl-catabolic bph gene clusters. Such hybrid strains gained the novel capability to grow on a wide range of aromatic hydrocarbons, and, more interestingly, they degraded chloroethenes such as trichloroethylene and cis-1,2-dichloroethylene very efficiently.

MeSH terms

  • Benzene Derivatives / metabolism*
  • Biodegradation, Environmental
  • Biphenyl Compounds / metabolism
  • Iron-Sulfur Proteins*
  • Oxygenases / genetics*
  • Protein Engineering
  • Pseudomonas / genetics*
  • Pseudomonas / metabolism
  • Recombinant Fusion Proteins
  • Toluene / metabolism
  • Trichloroethylene / metabolism*

Substances

  • Benzene Derivatives
  • Biphenyl Compounds
  • Iron-Sulfur Proteins
  • Recombinant Fusion Proteins
  • Trichloroethylene
  • diphenyl
  • Toluene
  • Oxygenases
  • toluene dioxygenase
  • biphenyl-2,3-dioxygenase