Three cases of medullo-epithelioma are reported from a study of almost 350 cases of retinoblastomas or pseudo-retinoblastomas. The cases concern one female and two male children of 1,5, 2,5 and 6 years of age respectively at the time of diagnosis. Suspected of carrying retinoblastoma, two of the children were enucleated. Histological examination revealed the presence of a benign medullo-epithelioma in one case and a malignant condition in the other. The third case was treated by brachytherapy which led to total destruction of the tumor. A new iridian focus opposite the original tumor appeared one year later and was in turn destroyed by cobalt applicator.