Abstract
A rare genetic type (Bf F1) of properdin factor B is found in 22.6% of patients with insulin-dependent diabetes mellitus but in only 1.9% of the general population, yielding a relative risk of 15.0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 to Bf, and that Bf F1 is a marker for nearly 1 out of 4 insulin-dependent diabetic patients.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Alleles
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Child
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Chromosome Mapping
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Chromosomes, Human, 6-12 and X*
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Complement Factor B / genetics*
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Diabetes Mellitus / drug therapy
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Diabetes Mellitus / genetics*
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Diabetes Mellitus / transmission
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Diabetes Mellitus, Type 1 / genetics
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Diseases in Twins*
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Enzyme Precursors / genetics*
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Female
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Humans
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Insulin / therapeutic use
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Male
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Pedigree
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Pregnancy
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Twins, Monozygotic
Substances
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Enzyme Precursors
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Insulin
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Complement Factor B