Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia

Y Furukawa; T Okadome; M Tara; K Niina; S Izumo; M Osame

doi:10.2169/internalmedicine.34.1130

Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia

Intern Med. 1995 Nov;34(11):1130-3. doi: 10.2169/internalmedicine.34.1130.

Authors

Y Furukawa¹, T Okadome, M Tara, K Niina, S Izumo, M Osame

Affiliation

¹ Third Department of Internal Medicine, Kagoshima University.

PMID: 8774979
DOI: 10.2169/internalmedicine.34.1130

Abstract

We report a 47-year-old Japanese woman with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) combined with acute type adult T-cell leukemia (ATL). The susceptibility for HAM/TSP and acute type of ATL is hitherto explained by human leukocyte antigen (HLA) haplotype-linked immune responsiveness to HTLV-I. This patient's HLA (A24Cw1B54DR4DQ4/A24Cw3B51DR8DQ1) included a HAM-associated HLA haplotype. This suggests that HAM patients with HAM-associated HLA haplotype can also develop the acute type of ATL.

Publication types

Case Reports

MeSH terms

Adult
Fatal Outcome
Female
HLA Antigens / immunology*
Haplotypes
Humans
Leukemia-Lymphoma, Adult T-Cell / complications*
Leukemia-Lymphoma, Adult T-Cell / immunology
Leukemia-Lymphoma, Adult T-Cell / pathology
Paraparesis, Tropical Spastic / complications*
Paraparesis, Tropical Spastic / etiology*
Paraparesis, Tropical Spastic / immunology
Paraparesis, Tropical Spastic / pathology

Substances

HLA Antigens