Second temporal remission in a malignant glioma with trofosfamide and etoposide: a case report

Klin Padiatr. 1996 Jul-Aug;208(4):190-2. doi: 10.1055/s-2008-1046472.

Abstract

A case of a malignant childhood glioma is reported with tumor-progression after surgery and radiotherapy during chemotherapy with cisplatinum, vincristine and CCNU, that responded temporally to oral treatment with VP16 and trofosfamide. A Phase II study with this combination is suggested.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Brain / pathology
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Chemotherapy, Adjuvant
  • Child, Preschool
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects
  • Cyclophosphamide / analogs & derivatives
  • Etoposide / administration & dosage
  • Etoposide / adverse effects
  • Female
  • Glioma / diagnostic imaging
  • Glioma / drug therapy*
  • Glioma / pathology
  • Humans
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / pathology
  • Radiography

Substances

  • Antineoplastic Agents, Alkylating
  • Etoposide
  • Cyclophosphamide
  • trofosfamide