Abstract
We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Amino Acid Sequence
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Animals
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Cell Line
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Chromosome Mapping
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Cloning, Molecular
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Cytokines / pharmacology
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DNA, Complementary / genetics
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Endosomal Sorting Complexes Required for Transport
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Humans
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Mice
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Molecular Sequence Data
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Molecular Weight
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Phosphoproteins / chemistry
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Phosphoproteins / genetics*
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Phosphoproteins / metabolism
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Phosphorylation
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Proteins / chemistry
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Proteins / genetics*
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Proteins / metabolism
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Receptors, Cytokine / metabolism
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Sequence Homology, Amino Acid
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Signal Transduction*
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Tyrosine / metabolism
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src Homology Domains
Substances
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Adaptor Proteins, Signal Transducing
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Cytokines
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DNA, Complementary
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Endosomal Sorting Complexes Required for Transport
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Phosphoproteins
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Proteins
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Receptors, Cytokine
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STAM protein, human
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Stam protein, mouse
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Tyrosine
Associated data
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GENBANK/U43899
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GENBANK/U43900