Precore mutant of hepatitis B virus prevails in acute and chronic infections in an area in which hepatitis B is endemic

J Clin Microbiol. 1996 Jul;34(7):1815-8. doi: 10.1128/JCM.34.7.1815-1818.1996.

Abstract

By using an amplification-created restriction site method, the precore TAG mutant of hepatitis B virus was detected in 6 (75%) of 8 acute fulminant hepatitis B patients, 7 (58%) of 12 acute self-limiting hepatitis B patients, 35 (81%) of 43 hepatitis B virus surface antigen carriers with fulminant hepatitis, and 42 (70%) of 60 hepatitis B virus surface antigen carriers with chronic hepatitis. The precore TAG mutant prevails in acute and chronic hepatitis B of various severity in this area where hepatitis B is endemic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Base Sequence
  • Carrier State / epidemiology
  • Carrier State / virology
  • Case-Control Studies
  • Chronic Disease
  • Codon, Terminator / genetics
  • DNA Mutational Analysis
  • DNA Primers / genetics
  • DNA, Viral / genetics
  • Hepatitis B / epidemiology
  • Hepatitis B / virology*
  • Hepatitis B e Antigens / genetics
  • Hepatitis B virus / genetics*
  • Humans
  • Point Mutation*
  • Taiwan / epidemiology

Substances

  • Codon, Terminator
  • DNA Primers
  • DNA, Viral
  • Hepatitis B e Antigens