Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

Genet Epidemiol. 1995;12(6):565-70. doi: 10.1002/gepi.1370120607.

Abstract

Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Chromosome Mapping
  • Computer Simulation*
  • Female
  • Gene Frequency
  • Genetic Diseases, Inborn / epidemiology*
  • Genetic Markers
  • Genetic Variation*
  • Humans
  • Male
  • Models, Genetic*
  • Prevalence
  • Risk Assessment

Substances

  • Genetic Markers