Two-locus approach of segregation and linkage analysis in the study of complex traits

Genet Epidemiol. 1995;12(6):825-30. doi: 10.1002/gepi.1370120649.

Abstract

A two-locus segregation and linkage-analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two-locus Mendelian model fit the data significantly better than a one-locus model. The linkage results based on the most parsimonious two-locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one-locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two-locus models.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Chromosome Mapping / methods*
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 2
  • Evaluation Studies as Topic
  • Genetic Diseases, Inborn / genetics*
  • Genetic Linkage*
  • Genetic Markers*
  • Humans
  • Models, Genetic
  • Phenotype
  • Regression Analysis

Substances

  • Genetic Markers