Abstract
Genetic and biochemical approaches are shedding new light on the distinct physiological functions of specific phospholipid metabolic pathways and the mechanisms by which phospholipids are mobilized between intracellular compartments. In particular, phosphatidylinositol-transfer proteins have recently been revealed to play fascinating and unanticipated roles in the coordination of phospholipid metabolism with vesicle-trafficking and signal-transducing reactions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Biological Transport / genetics
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Carrier Proteins / metabolism*
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Membrane Proteins*
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Membranes / metabolism
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Models, Biological
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Phospholipid Transfer Proteins
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Phospholipids / metabolism*
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Saccharomyces cerevisiae Proteins*
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Signal Transduction
Substances
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Carrier Proteins
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Membrane Proteins
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Phospholipid Transfer Proteins
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Phospholipids
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SEC24 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins