Imipramine: a model drug for P450 research

Methods Enzymol. 1996:272:177-86. doi: 10.1016/s0076-6879(96)72022-0.

Authors

K Brøsen¹, E Skjelbo, K K Nielsen

Affiliation

¹ Department of Clinical Pharmacology, Institute of Medical Biology, Odense University, Denmark.

PMID: 8791776
DOI: 10.1016/s0076-6879(96)72022-0

No abstract available

MeSH terms

Antidepressive Agents, Tricyclic / analysis
Antidepressive Agents, Tricyclic / metabolism*
Antidepressive Agents, Tricyclic / pharmacokinetics
Biotransformation
Chromatography, High Pressure Liquid / methods
Cytochrome P-450 CYP2D6 / metabolism
Cytochrome P-450 Enzyme System / metabolism*
Humans
Imipramine / analysis
Imipramine / metabolism*
Imipramine / pharmacokinetics
In Vitro Techniques
Microsomes, Liver / metabolism
Models, Biological
NADP / metabolism

Substances

Antidepressive Agents, Tricyclic
NADP
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP2D6
Imipramine