Abstract
Although uncommon, torsades de pointes (TdP) associated with astemizole and/or erythromycin use have been reported previously. We describe a 30-year-old woman who had congenital prolongation of QT interval and TdP occurred after taking astemizole and erythromycin. Temporary cardiac pacing was successful in suppressing TdP. Prolongation of QT interval had good response to oral propranolol.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Arrhythmia Agents / therapeutic use
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / therapeutic use
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Astemizole / adverse effects*
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Astemizole / therapeutic use
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Cardiac Pacing, Artificial
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Electrocardiography
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Erythromycin / adverse effects*
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Erythromycin / therapeutic use
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Female
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Histamine H1 Antagonists / adverse effects*
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Histamine H1 Antagonists / therapeutic use
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Humans
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Long QT Syndrome / complications
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Long QT Syndrome / therapy*
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Propranolol / therapeutic use
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Rhinitis / complications
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Rhinitis / drug therapy
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Torsades de Pointes / chemically induced*
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Torsades de Pointes / complications
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Torsades de Pointes / therapy
Substances
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Anti-Arrhythmia Agents
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Anti-Bacterial Agents
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Histamine H1 Antagonists
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Erythromycin
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Astemizole
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Propranolol