Influence of smoking in the glutathione-S-transferase M1 deficiency--associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt

A Lafuente; M M Zakahary; M A el-Aziz; C Ascaso; M J Lafuente; M Trias; P Carretero

doi:10.1038/bjc.1996.445

Influence of smoking in the glutathione-S-transferase M1 deficiency--associated risk for squamous cell carcinoma of the bladder in schistosomiasis patients in Egypt

Br J Cancer. 1996 Sep;74(5):836-8. doi: 10.1038/bjc.1996.445.

Authors

A Lafuente¹, M M Zakahary, M A el-Aziz, C Ascaso, M J Lafuente, M Trias, P Carretero

Affiliation

¹ Institut de Salut Pública, University of Barcelona, Spain.

Abstract

In this study we show an effect of the glutathione-S-transferase M1 (GSTM1) null phenotype on the risk for squamous cell carcinoma (SCC) of the bladder among male smokers in Egypt, with an adjusted odds ratio of 4.8 (95% confidence interval: 1.06-21.77). However, no overall effect of the GSTM1 null phenotype on the risk for bladder SCC was observed.

MeSH terms

Adult
Age Factors
Carcinoma, Squamous Cell / etiology*
Chi-Square Distribution
Disease Susceptibility
Egypt / epidemiology
Female
Glutathione Transferase / deficiency*
Glutathione Transferase / genetics
Humans
Incidence
Male
Middle Aged
Odds Ratio
Phenotype
Risk Factors
Schistosomiasis / complications*
Schistosomiasis / pathology
Smoking / adverse effects*
Urinary Bladder Neoplasms / epidemiology
Urinary Bladder Neoplasms / etiology*

Substances

Glutathione Transferase