Abstract
To understand the normal function of the prion protein (PrP) and its role in prion disorders, several groups have generated mice lacking PrP. Some of these mice develop symptoms associated with prion diseases, but other experimental evidence suggests that the loss of functional PrP is not the instigating factor in these disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Disease Models, Animal
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Humans
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Mice
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Mice, Knockout
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Mice, Transgenic
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Phenotype
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PrPC Proteins / pathogenicity
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PrPSc Proteins / genetics
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PrPSc Proteins / pathogenicity
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Prion Diseases / etiology*
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Prions / genetics
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Prions / pathogenicity*
Substances
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PrPC Proteins
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PrPSc Proteins
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Prions