Abstract
Natural killer (NK) and T cells express receptors for polymorphic major histocompatibility complex (MHC) class I molecules, and activation of these receptors results in inhibition of their effector cell function. Genes encoding the murine and human NK-cell receptors have been cloned, and studies of their structure, function and expression are progressing rapidly, as reviewed here by Lewis Lanier and Joseph Phillips.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Gene Expression Regulation
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Histocompatibility Antigens Class I / immunology*
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Humans
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Killer Cells, Natural / immunology*
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Receptors, Immunologic / antagonists & inhibitors
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology*
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T-Lymphocytes / immunology*
Substances
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Histocompatibility Antigens Class I
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Receptors, Immunologic