Abstract
Three known sesquiterpenoids of the lactarane and secolactarane type, deoxylactarorufin A (1), blennin A (2) and blennin C (3), have been obtained from cultures of Lentinellus cochleatus (Basidiomycetes) together with the new metabolites (Z)-2-chloro-3-(4-methoxyphenyl)-2-propen-1-ol (4) and lentinellone (5), a protoilludane derivative. The structures were determined by spectroscopic investigations. 1, 2 and 3 are potent inhibitors of leukotriene biosynthesis in rat basophilic leukemia (RBL-1) cells and human peripheral blood leukocytes (PBL).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Bacteria / drug effects
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Basidiomycota* / growth & development
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Basidiomycota* / metabolism
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Cell Line
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Chromatography, Thin Layer / methods
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Culture Media
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Dinoprostone / biosynthesis
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Dinoprostone / blood
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Fermentation
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Fungi / drug effects
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Humans
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Leukemia, Basophilic, Acute
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Leukocytes / drug effects
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Leukocytes / metabolism*
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Leukotriene Antagonists
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Leukotriene B4 / biosynthesis
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Leukotriene B4 / blood
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Leukotriene C4 / biosynthesis
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Leukotriene C4 / blood
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Leukotrienes / biosynthesis*
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Microbial Sensitivity Tests
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Molecular Structure
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Rats
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Culture Media
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Leukotriene Antagonists
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Leukotrienes
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Sesquiterpenes
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Leukotriene B4
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Leukotriene C4
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Dinoprostone