Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria

P L Chiodini; C P Conlon; D B Hutchinson; J A Farquhar; A P Hall; T E Peto; H Birley; D A Warrell

doi:10.1093/jac/36.6.1073

Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria

J Antimicrob Chemother. 1995 Dec;36(6):1073-8. doi: 10.1093/jac/36.6.1073.

Authors

P L Chiodini¹, C P Conlon, D B Hutchinson, J A Farquhar, A P Hall, T E Peto, H Birley, D A Warrell

Affiliation

¹ Department of Clinical Parasitology, Hospital for Tropical Diseases, London.

PMID: 8821609
DOI: 10.1093/jac/36.6.1073

Abstract

The activity of atovaquone in patients with oligosymptomatic Plasmodium falciparum malaria was assessed in an open, non-comparative clinical study. The patients showed a good clinical response, but there was a high rate of recrudescence. The activity of atovaquone in combination with another antimalarial agent should be investigated.

Publication types

Clinical Trial

MeSH terms

Adult
Antimalarials / adverse effects
Antimalarials / blood
Antimalarials / therapeutic use*
Atovaquone
Dose-Response Relationship, Drug
Drug Administration Schedule
Evaluation Studies as Topic
Humans
Malaria, Falciparum / blood
Malaria, Falciparum / drug therapy*
Male
Middle Aged
Naphthoquinones / adverse effects
Naphthoquinones / blood
Naphthoquinones / therapeutic use*
Treatment Outcome

Substances

Antimalarials
Naphthoquinones
Atovaquone