Production of [18F]F2 using the 16O(3He,p)18F reaction

Nucl Med Biol. 1996 May;23(4):385-9. doi: 10.1016/0969-8051(95)02009-8.

Abstract

For the first time, the 16O(3He,p)18F reaction has been used for the production of 18F electrophilic reagents. The predominant reactive chemical specie recovered in the single-step postirradiation gases was [18F]F2. Decay curve and Ge(Li) analyses established the main radionuclidic impurities in this nuclear reaction as 11C and 15O. Recovery of the 18F activity was exceptionally high, approaching 90% using an electroformed nickel target body. Consistent 18F recoveries for this nuclear reaction (approximately 70%) were realized with a novel aluminum target body. The utility of the [18F]F2 recovered from this oxygen gas target system in radiopharmaceutical preparations is demonstrated by the successful synthesis of 6-[18F]fluoro-L-dopa (11.0 mCi at EOB) via a fluorodemercuration method.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Fluorine Radioisotopes / chemistry*
  • Fluorine Radioisotopes / isolation & purification
  • Gases
  • Helium / chemistry*
  • Isotope Labeling / methods
  • Oxygen / chemistry*
  • Radiochemistry / methods*

Substances

  • Fluorine Radioisotopes
  • Gases
  • Helium
  • Oxygen