The Human Genome Project is essentially on schedule in accomplishing its short-term goals. Extensive genetic maps and partial physical maps have been made of all the chromosomes, an achievement which has accelerated the rate at which genes are being cloned. Preliminary to the concerted sequencing efforts that will occupy the later years of the Project, extensive activity has been directed toward the development of conventional and novel sequencing methods. The impact that the Human Genome Project will have on society and the future of medicine is discussed.