Chromosomal mapping of human angiotensinogen gene and human renin gene by fluorescence in situ hybridization (FISH) in transgenic mice

Y Watanabe; M Ebukuro; K Yagami; F Sugiyama; J Ishida; K Murakami; T Nomura; H Katoh

doi:10.1538/expanim.45.265

Chromosomal mapping of human angiotensinogen gene and human renin gene by fluorescence in situ hybridization (FISH) in transgenic mice

Exp Anim. 1996 Jul;45(3):265-9. doi: 10.1538/expanim.45.265.

Authors

Y Watanabe¹, M Ebukuro, K Yagami, F Sugiyama, J Ishida, K Murakami, T Nomura, H Katoh

Affiliation

¹ Department of Genetics, Central Institute for Experimental Animals, Kanagawa, Japan.

PMID: 8840145
DOI: 10.1538/expanim.45.265

Abstract

We attempted to apply FISH to chromosomal mapping of the human angiotensinogen (hAG) and human renin (hRN) transgenes which are carried by the parental strains of the Tsukuba hypertensive mouse. We report here that the hAG gene is mapped in the C2 region of Chr 19 and the hRN gene in the A1 region of Chr 6.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiotensinogen / genetics*
Animals
Chromosome Mapping / methods*
DNA / isolation & purification
Female
Genetic Linkage
Humans
Hypertension / genetics
In Situ Hybridization, Fluorescence / methods
Karyotyping
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Renin / genetics*

Substances

Angiotensinogen
DNA
Renin