Von Wille-brand's disease in UK dobermanns: possible correlation of a polymorphic DNA marker with disease status

N G Holmes; S C Shaw; H F Dickens; L M Coombes; E J Ryder; J D Littlewood; M M Binns

doi:10.1111/j.1748-5827.1996.tb02394.x

Von Wille-brand's disease in UK dobermanns: possible correlation of a polymorphic DNA marker with disease status

J Small Anim Pract. 1996 Jul;37(7):307-8. doi: 10.1111/j.1748-5827.1996.tb02394.x.

Authors

N G Holmes¹, S C Shaw, H F Dickens, L M Coombes, E J Ryder, J D Littlewood, M M Binns

Affiliation

¹ Centre for Preventive Medicine, Animal Health Trust, Newmarket, Suffolk.

PMID: 8840249
DOI: 10.1111/j.1748-5827.1996.tb02394.x

Abstract

Ninety-one dobermanns have been typed for a polymorphic microsatellite DNA marker situated within an intron of the von Willebrand factor gene and the alleles correlated with von Wille-brand's disease status. Two alleles were identified, one associated only with the normal gene and the other with both normal and disease genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Animals
Dog Diseases / genetics*
Dogs
von Willebrand Diseases / genetics
von Willebrand Diseases / veterinary*
von Willebrand Factor / genetics*

Substances

von Willebrand Factor