Failure of pretreatment with intravenous folic acid to alter the cumulative hematologic toxicity of lometrexol

J Natl Cancer Inst. 1996 Oct 16;88(20):1495-6. doi: 10.1093/jnci/88.20.1495.
No abstract available

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / pharmacokinetics
  • Drug Administration Schedule
  • Female
  • Folic Acid / administration & dosage
  • Folic Acid / therapeutic use*
  • Folic Acid Antagonists / adverse effects*
  • Folic Acid Antagonists / pharmacokinetics
  • Humans
  • Infusions, Intravenous
  • Male
  • Neoplasms / drug therapy
  • Pancytopenia / chemically induced
  • Pancytopenia / prevention & control*
  • Stomatitis / chemically induced
  • Stomatitis / prevention & control*
  • Tetrahydrofolates / adverse effects*
  • Tetrahydrofolates / pharmacokinetics
  • Treatment Failure

Substances

  • Antimetabolites, Antineoplastic
  • Folic Acid Antagonists
  • Tetrahydrofolates
  • lometrexol
  • Folic Acid