A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments

Mol Biochem Parasitol. 1996 Jul;79(1):129-33. doi: 10.1016/0166-6851(96)02649-7.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Drug Resistance / genetics
  • Genetic Markers*
  • Leishmania major / enzymology
  • Leishmania major / genetics*
  • Methotrexate / pharmacology
  • Multienzyme Complexes / genetics*
  • Mutation*
  • Selection, Genetic
  • Tetrahydrofolate Dehydrogenase / genetics*
  • Thymidylate Synthase / genetics*
  • Transfection / methods*

Substances

  • Genetic Markers
  • Multienzyme Complexes
  • thymidylate synthase-dihydrofolate reductase
  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase
  • Methotrexate