Transgenic and knockout mice in the study of neurodegenerative diseases

J Mol Med (Berl). 1996 Mar;74(3):111-26. doi: 10.1007/BF01575443.

Abstract

Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Humans
  • Mice
  • Mice, Knockout*
  • Mice, Transgenic*
  • Nerve Degeneration
  • Nervous System Diseases*