Abstract
Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the 78 resistant organisms had missense mutations in codon 43 of rpsL resulting in a K-43-->R substitution. Mutations in codon 88 of rpsL were also identified in four Asian isolates.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibiotics, Antitubercular / pharmacology*
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Base Sequence
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Molecular Sequence Data
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics*
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RNA, Ribosomal, 16S / genetics*
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Ribosomal Proteins / genetics*
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Sequence Homology
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Streptomycin / pharmacology*
Substances
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Antibiotics, Antitubercular
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RNA, Ribosomal, 16S
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Ribosomal Proteins
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ribosomal protein S12
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Streptomycin
Associated data
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GENBANK/L08011
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GENBANK/X52917