Langerhans cell histiocytosis, diabetes insipidus, hyperprolactinemia and empty sella: a four-fold association. Report of two cases

N Panza; B Merola; A Colao; G Iodice; A de Bellis; A Bizzarro; A Bellastella; G Lombardi

doi:10.1007/BF03347857

Langerhans cell histiocytosis, diabetes insipidus, hyperprolactinemia and empty sella: a four-fold association. Report of two cases

J Endocrinol Invest. 1996 Jan;19(1):43-7. doi: 10.1007/BF03347857.

Authors

N Panza¹, B Merola, A Colao, G Iodice, A de Bellis, A Bizzarro, A Bellastella, G Lombardi

Affiliation

¹ Settore di Immunologia ed Endocrinologia Oncologica, Ospedale A. Cardarelli, Napoli, Italy.

PMID: 8851691
DOI: 10.1007/BF03347857

Abstract

Two cases of Langerhans cell histiocytosis (LCH) expressing as Hand-Schuller-Christian syndrome with diabetes insipidus, hyperprolactinemia and empty sella are here reported. Up-to-date this four-fold association is lacking in world literature and it is here discussed in the light if LCH is a cancer or the clinical expression of an immunologic disorder.

Publication types

Case Reports

MeSH terms

Adult
Diabetes Insipidus / blood
Diabetes Insipidus / physiopathology*
Empty Sella Syndrome / blood
Empty Sella Syndrome / pathology
Empty Sella Syndrome / physiopathology*
Female
Histiocytosis, Langerhans-Cell / blood
Histiocytosis, Langerhans-Cell / physiopathology*
Hormones / blood
Humans
Hyperprolactinemia / blood
Hyperprolactinemia / physiopathology*
Magnetic Resonance Imaging
Middle Aged

Substances

Hormones