Abstract
The effect of pretreatment with odansetron on prolactin (PRL) release induced by electroconvulsive therapy (ECT) was examined in 16 depressive patients in a double-blind, placebo-controlled crossover study. Ten patients were pretreated with 4 mg and the other six with 8 mg of ondansetron. The order of administration of study medication (ondansetron and placebo) was counterbalanced. The failure of ondansetron to attenuate ECT-induced PRL release suggested that serotonin3 receptors are not involved in mediating this response.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Adult
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Cross-Over Studies
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Depressive Disorder / drug therapy*
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Depressive Disorder / therapy*
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Double-Blind Method
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Electroconvulsive Therapy*
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Female
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Humans
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Male
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Middle Aged
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Ondansetron / pharmacology*
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Ondansetron / therapeutic use*
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Placebos
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Prolactin / blood
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Prolactin / metabolism*
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Receptors, Serotonin / drug effects*
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Serotonin / metabolism*
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Serotonin Antagonists / pharmacology*
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Serotonin Antagonists / therapeutic use*
Substances
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Placebos
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Receptors, Serotonin
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Serotonin Antagonists
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Serotonin
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Ondansetron
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Prolactin