The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques

Antiviral Res. 1996 Aug;32(1):1-8. doi: 10.1016/0166-3542(95)00955-8.

Abstract

The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antigens, Viral / blood
  • Biopterins / analogs & derivatives
  • Biopterins / blood
  • CD4 Lymphocyte Count
  • Gene Products, gag / blood
  • Gene Products, gag / immunology
  • Humans
  • Interferon Type I / administration & dosage
  • Interferon Type I / pharmacology*
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage
  • Interferon-alpha / pharmacology*
  • Macaca mulatta
  • Neopterin
  • Recombinant Proteins
  • Simian Acquired Immunodeficiency Syndrome / immunology
  • Simian Acquired Immunodeficiency Syndrome / therapy*
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / immunology
  • Time Factors

Substances

  • Antigens, Viral
  • Gag protein p27, Simian immunodeficiency virus
  • Gene Products, gag
  • Interferon Type I
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Biopterins
  • Neopterin