Abstract
Two renal proximal tubular apical sodium-dependent transport systems for phosphate (Na/Pi cotransporter) have been identified. Recent studies demonstrated that the abundance of the type II Na/Pi cotransporter in the brush border is critical for the capacity of phosphate reabsorption. Evidence was obtained that a change of apical Na/Pi cotransporters may occur via endo/ exocytic processes and via protein-synthesis-dependent mechanisms involving altered transcription and/or stability of mRNA. In addition, acute control of apical Na/Pi cotransport may occur via the pH dependence and electrogenicity of the Na/Pi cotransporter.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Carrier Proteins / biosynthesis
-
Carrier Proteins / metabolism*
-
Endocytosis
-
Exocytosis
-
Hydrogen-Ion Concentration
-
Kidney Tubules, Proximal / physiology*
-
Microvilli / metabolism
-
Models, Biological
-
Phosphates / metabolism
-
RNA, Messenger / metabolism
-
Sodium / metabolism
-
Sodium-Phosphate Cotransporter Proteins
-
Sodium-Phosphate Cotransporter Proteins, Type II
-
Symporters*
-
Transcription, Genetic
Substances
-
Carrier Proteins
-
Phosphates
-
RNA, Messenger
-
Sodium-Phosphate Cotransporter Proteins
-
Sodium-Phosphate Cotransporter Proteins, Type II
-
Symporters
-
Sodium