Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute lithium

Eur Neuropsychopharmacol. 1996 Mar;6(1):39-41. doi: 10.1016/0924-977x(95)00054-s.

Abstract

Chronic lithium treatment in rats has been reported to decrease protein kinase C alpha isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Injections, Spinal
  • Lithium / pharmacology*
  • Male
  • Motor Activity / drug effects*
  • Phorbol Esters / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors

Substances

  • Phorbol Esters
  • Lithium