Abstract
The effect of majonoside-R2 on morphine- and U-50,488H-induced antinociception was examined by the tail-pinch test in mice and compared with that of diazepam. Majonoside-R2 and diazepam inhibited the morphine- and U-50,488H-induced antinociception, and the actions were antagonized by the benzodiazepine receptor antagonist flumazenil and the GABA-gated CI- channel blocker picrotoxin. Diazepam but not majonoside-R2 exhibited a protective activity against convulsion caused by the GABAA antagonists bicuculline and picrotoxin. These results indicate that GABAA systems are involved in the effect of majonoside-R2 on the opioid-induced antinociception and suggest that the mechanisms of action of majonoside-R2 may differ from those of diazepam.
MeSH terms
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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Analgesics / antagonists & inhibitors
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Analgesics, Opioid / antagonists & inhibitors
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Analysis of Variance
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Animals
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Convulsants
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Diazepam / antagonists & inhibitors
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Diazepam / pharmacology
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Dose-Response Relationship, Drug
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Flumazenil / pharmacology
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GABA Modulators / antagonists & inhibitors
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GABA Modulators / pharmacology
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Ginsenosides*
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Male
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Mice
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Morphine / antagonists & inhibitors
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Pain Measurement / drug effects*
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Picrotoxin
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Pyrrolidines / antagonists & inhibitors
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Saponins / antagonists & inhibitors
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Saponins / pharmacology*
Substances
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Analgesics
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Analgesics, Opioid
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Convulsants
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GABA Modulators
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Ginsenosides
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Pyrrolidines
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Saponins
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Picrotoxin
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Flumazenil
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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
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Morphine
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majonoside R2
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Diazepam