Urinary N-acetyl-beta-D-glucosaminidase and beta 2-microglobulin excretion in primary nephrotic children

Nephron. 1996;74(2):401-4. doi: 10.1159/000189442.

Abstract

Enzymuria and low molecular weight proteinuria reflect tubular damage and dysfunction, respectively. We examined urinary N-acetyl-beta-D-glucosaminidase (U-NAG) and beta 2-microglobulin (U-beta 2M) excretion in 17 steroid-resistant and 39 steroid-sensitive children with nephrotic syndrome whose glomerular filtration rates were within the normal range. Fourteen healthy children were taken as controls. U-NAG and U-beta 2M levels did not show a difference between the steroid-resistant and steroid-sensitive groups but were significantly higher in the nephrotic groups compared to the controls (p < 0.0001 and p < 0.01, respectively). In the steroid-sensitive group, U-NAG levels were significantly higher in patients in the relapse phase than in those in remission (p < 0.0001). This finding was also valid for U-beta 2M excretion, but reached significance only for patients in remission who did not receive steroids (p < 0.01). There was a positive correlation between proteinuria and U-NAG and U-beta 2M excretion in all patients (rs = 0.69, p < 0.001 and rs = 0.39, p < 0.001, respectively). In conclusion, massive glomerular proteinuria may cause a marked U-NAG excretion and a moderate urinary U-beta 2M elevation independent of primary renal disease.

MeSH terms

  • Acetylglucosaminidase / urine*
  • Adolescent
  • Biomarkers / urine
  • Child
  • Child, Preschool
  • Glomerular Filtration Rate
  • Glomerular Mesangium / pathology
  • Glomerulonephritis, Membranoproliferative / urine
  • Humans
  • Infant
  • Nephrotic Syndrome / enzymology
  • Nephrotic Syndrome / urine*
  • Recurrence
  • Reference Values
  • beta 2-Microglobulin / urine*

Substances

  • Biomarkers
  • beta 2-Microglobulin
  • Acetylglucosaminidase