Abstract
The occurrence of conserved epitopes in the immune system was investigated on the leukocytes of cattle, river buffalo, sheep, camel, swine and humans by indirect immunofluorescence and flow cytometry. The distribution of the most conservative epitopes on leukocyte sub-populations suggests that the expression pattern of the proteins is similar. Western blotting experiments indicate that the recognized antigens are structural homologues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Monoclonal / immunology
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Blotting, Western
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Conserved Sequence / immunology*
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Cross Reactions / immunology
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Epitopes / biosynthesis
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Epitopes / immunology*
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Evolution, Molecular*
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Flow Cytometry
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Histocompatibility Antigens Class I / biosynthesis
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Histocompatibility Antigens Class I / immunology*
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Histocompatibility Antigens Class II / biosynthesis
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Histocompatibility Antigens Class II / immunology*
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Humans
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Major Histocompatibility Complex / immunology*
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Phylogeny*
Substances
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Antibodies, Monoclonal
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Epitopes
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II